Forensic evaluation of this Big 12 conference matchup isolates marginal pricing inefficiencies across standard market tiers. Iowa State hosts West Virginia with both squads returning on identical 7-day rest cycles following opening-week conference defeats. Market pricing establishes the Cyclones as moderate home favorites, yet defensive vulnerabilities against the run identified in recent outings create situational value on compressed alternate spread bands and total efficiency vectors. We exploit micro-discrepancies in the bookmaker lines while strictly anchoring our mathematical models to baseline market probabilities to capture sustainable value edges.