Penn State hosts Buffalo in a lopsided mismatch characterized by contrasting defensive efficiencies and travel fatigue for the visitors. The Nittany Lions have completely neutralized opponents, surrendering a meager nine total points across their first two outings. Meanwhile, Buffalo's porous defense allowed 540 yards to FIU and now faces an elite physical unit. Market lines heavily favor the home side, creating compressed margins, yet specific secondary markets offer calculated value via disciplined Poisson distributions.